GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine, first isolated from human plasma in 1973.

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GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine, first isolated from human plasma in 1973. Plasma levels decline with age from roughly 200 ng/ml at age 20 to about 80 ng/ml by age 60. This copper peptide supports collagen and elastin synthesis, wound healing, antioxidant defense, and anti-inflammatory activity while modulating thousands of genes toward healthier expression patterns. Widely used in skincare as Copper tripeptide-1, GHK-Cu improves skin firmness, reduces wrinkles, and aids tissue regeneration. Research also explores benefits for hair and broader regenerative applications. Available in topical serums and research forms; not FDA-approved as a drug.